NSS Labs the well-respected UK-based security product research and testing service, just published the results of its consumer anti-malware test. The most popular products, Symantec and McAfee, both came it at only 82%. Therefore you cannot rely on this single security control to protect you against malware. A layered, defense-in-depth strategy is a must.
While all organizations are different, complementary technologies include Secure Web Gateways, Intrusion Prevention, Data Leak Prevention, or an advanced firewall that performs all of these functions, and possibly a Security Information and Event Management System. If you are running web applications, you will also need a Web Application Firewall. I wrote about this in my post about the 20 Top Security Controls.
The top vendor was Trend Micro with a 96% success rate when you combine the 91% caught at download time and the 5.5% caught at execution time. I also read about this report in an article at Dark Reading written by Tim Wilson. However, Tim said Trend Micro only blocked 70% of the malware. I am not sure where he got his number.